Overview

Dysregulation of the innate immune system is now seen to play a role in many chronic disease states. The TH1 and TH2 responses are two distinct pathways that regulate defense mechanisms while maintaining immune homeostasis. Their roles and interactions are critical for balancing appropriate pro-inflammatory and anti-inflammatory responses.

When the TH1 response dominates, the result triggers autoimmune diseases, chronic systemic and neurological inflammation and tissue damage. TH2 dominance leads to allergies, asthma, eczema, impaired defense against viruses and fibrosis.

Our focus is on TH1 dominance, which is characterised by overexpression of proinflammatory cytokines that, over time, disrupt the function of critical cellular processes that are responsible for the integrity of various organ systems, particularly the central nervous system.

Our research is focussed on restoring TH1/Th2 balance, thereby creating a novel approach to managing several disorders.